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Blog: NanoBRET Target Engagement Kinase Assay

Kinases are one of the most significant classes of drug targets because of their involvement in several diseases including cancer, osteoporosis, inflammatory disease, diabetes and neurodegeneration. Identification of candidate drugs targeting kinases relies on...

Article: Kinase Profiling

The role of kinases in human disease is well known in the drug discovery world, making them significant therapeutic intervention points. There are over 500 known kinases in the human kinome and over 150 are mutated or mis regulated in various disease states. However,...

GPCRs and their significance in the pharmaceutical world

GPCRs (G-protein-coupled receptors) are the largest and most diverse family of membrane proteins that transduce extracellular stimuli into intracellular signals. Their association with several human diseases has made them a hot topic of research in the pharmaceutical...

Dysregulation in Autophagy

Autophagy is an evolutionarily conserved process essential for survival, differentiation, development, and homeostasis. However, its involvement in several diseases has been established for many years. Read our blog below to learn more about autophagy and some common...