We specialise in physiologically relevant assays using cell-based formats in state of the art technologies i.e. phenotypic screening.
We have used a number of human primary cells in different assay formats. Example:
- Measurement of calcium mobilisation from neutrophils following agonist addition in the presence or absence of compounds using FLIPR in 384 well and 1536 well format.
- Measurement of superoxide burst from cells stimulated with and in the presence of compounds using chemiluminescence substrates.
- Measurement of activation of cells via surface measurement changes and the dissection of G-protein coupled events detected using label-free technology and as a replacement to whole blood CD11b assays.