0115 837 0503 info@aureliabio.com

Phenotypic Screening

We specialise in physiologically relevant assays using cell-based formats in state of the art technologies. We have used a number of human primary cells in a number of assay formats.

High Content Screening

High Content Screening (HCS) uses microscopic imaging to observe, measure and analyse multiple parameters within cells in a biological assay.

WES: Western Assay System

The WesTM system from ProteinSimple is a fully automated device which runs the Simple Western size assay; a highly reproducible and sensitive alternative to standard Western blotting assays.

3-D Cell Biology

We have developed a 3-D micro-tissue system from electrospun material that can be used in conjunction with well plates for higher throughput screening. Additionally, we use Ultra Low Attachment (ULA) plates to generate and culture spheroids.

Label-Free Screening

Our scientists have in-depth experience of label-free technology applied to cell-based assays gained over the past 6 years using Corning Epic, PerkinElmer EnSpire and SRU Bioscience Bind instruments.

Cell-Based Screening

Cell based assays are of key importance at a number of stages in the drug discovery process. Being able to examine the interaction between your target and compounds in a cellular context is of great advantage.

High Throughput Screening

With over 20 years of screening experience we are adept at designing screening assays and screening 100,000 to 1 million compounds in 384 well and 1536 well plates.

FLIPR Screening

We use FLIPR in a range of assay formats, readouts and target types.

Cell Culture Services

Typical screens have required upwards of 1010 cells. We have developed methodologies to grow, sub-culture, harvest, cryopreserve and revive these quantities of cells from single batches, thus reducing screening variability, allowing cells to be used in an identical manner to other assay reagents, reviving and using what is required on a daily basis.

Flow Cytometry

Flow cytometry can simultaneously analyse multiple parameters such as relative size, internal complexity, relative fluorescence intensity, etc on the same cell within seconds. 

Quantitative PCR

Using our Applied Biosystems™ QuantStudio™ 6 Flex Real-Time PCR system, we are able to investigate quantitative differences in mRNA expression in relation to pathways and targets identified as being of interest to clients. 

Biochemical Screening

We have carried out biochemical screening for a range of targets including but not limited to proteases, kinases, phosphodiesterase enzymes and protein:protein interactions.

Instrument and Reagent Validation

Acting as an intermediary between instrument manufacturers and reagent manufacturers and prospective clients, we can provide an expert lab-based environment for the validation of new technologies.

Target Engagement kinase profiling service

Using Promega’s NanoBRET™ technology, we have employed intracellular kinase assays designed to study the interaction of compounds on kinase targets in intact living cells.

Customised bioassay development, pharmacological profiling and compound screening

Conference: ELRIG Drug Discovery 2019

Aurelia Bioscience exhibited and presented posters at ELRIG Drug Discovery 2019 in Liverpool, UK on 5th and 6th November. Follow the link for a copy of the posters.

Video: 3D Cell Culture Technology Poster

Watch our latest video that describes our poster on ‘Magnetic Electrospun Micro-fibre Scaffold Assemblies…

Conference: CHI Discovery on Target

Aurelia Bioscience exhibited at the CHI Discovery on Target 2019 conference in Boston from 16th-19th September.

Video: Protein-protein interactions poster

Watch this exciting video to learn more about our poster on ‘Screening for inhibitors of…

Blog: Validating innovative solutions in cell biology: A case study

New, innovative solutions in cell biology are constantly being developed to support…

Conference: CHI World Pre-clinical Congress

Aurelia Bioscience exhibited and presented a poster on 'Magnetic Electrospun Micro-fibre Scaffold Assemblies: Examples of their use for 3-Dimensional Cell-Based Screening Applications' at CHI World Pre-clinical Congress in Boston. Follow the link to download the poster.

Are you looking for a CRO to help you discover your next breakthrough drug?