Bioassays & Screening
Aurelia Bioscience Ltd is a pre-clinical contract research company focusing on supplying biochemical and cell-based compound screening expertise to small to medium enterprise (SME) companies, universities, research institutes, charities and large pharmaceuticals companies.
Our vision is to be recognised by our clients, partners and peers as a centre of excellence for these activities. Underlying this is a desire to continue to contribute to the discovery of new therapeutic compounds for unmet medical need.
Capabilities
High Throughput Screening
With over 20 years of screening experience we are adept at designing and screening over 100,000 to 1 million compounds in 384 and 1536 well plates.
Cell Culture Services
With over 30 years of experience we are adept at all aspects of cell culture.
Phenotypic Screening
We specialise in physiologically relevant assays using predominantly cell-based formats in state of the art technologies.
Bio Chemical Screening
Our team has extensive experience of developing and screening compounds in biochemical assays for a range of targets including but not limited to proteases, kinases, and phosphodiesterase enzymes and protein:protein interaction.
Cell-Based Screening
Cell based assays are of key importance at a number of stages in the drug discovery process. Being able to examine the interaction between your target and compounds in a cellular context is of great advantage.
Label-Free Screening
Our scientists have in-depth experience of label-free technology applied to cell-based assays gained over the past 6 years using Coring EPIC, Perkin Elmer EnSpire and SRU Bioscience Bind instruments.
FLIPR Screening
We have used FLIPR in a range of assay formats, readouts and target types.
FMAT Screening
The 8200 Cellular Detection System (Fluorescent Microvolume Assay Technology – FMAT) from Applied Biosystems is a laser scanning macro-confocal fluorescent plate reader.
High Content Screening
We have used the Ultra and Micro HCS imaging devices in a range of assay formats involving different target types.
Our People
Scientists at Aurelia have decades of experience between them working in real-world drug discovery projects utilising FLIPR, FMAT, EPIC label free and Envision-based assays in both biochemical and cell-based formats
Services
Fee for Service
A comprehensive service to drug discovery clients including assay development, reagent testing and scale-up, proof of technology concept and validation, phenotypic screening and consultancy.
Drug Discovery Project
The members of Aurelia Bioscience have been involved in the design and development of many drug discovery projects incorporating complex biology and implementing a suite of assays designed to identify “active” compounds and improve their biological properties.
Instrument & Reagent Development
Acting as an intermediary between instrument and reagent manufacturers and prospective clients we can provide an expert lab-based environment for the validation of new technologies.