Phenotypic Screening

We specialise in physiologically relevant assays using cell-based formats in state of the art technologies. We have used a number of human primary cells in a number of assay formats.

High Content Screening

High Content Screening (HCS) uses microscopic imaging to observe, measure and analyse multiple parameters within cells in a biological assay.

Label-Free Screening

Our scientists have in-depth experience of label-free technology applied to cell-based assays gained over the past 6 years using Corning Epic, PerkinElmer EnSpire and SRU Bioscience Bind instruments.

Cell-Based Screening

Cell based assays are of key importance at a number of stages in the drug discovery process. Being able to examine the interaction between your target and compounds in a cellular context is of great advantage.

Cell Culture Services

Typical screens have required upwards of 1010 cells. We have developed methodologies to grow, sub-culture, harvest, cryopreserve and revive these quantities of cells from single batches, thus reducing screening variability, allowing cells to be used in an identical manner to other assay reagents, reviving and using what is required on a daily basis.

Target Engagement kinase profiling service

Using Promega’s NanoBRET™ technology, we have employed intracellular kinase assays designed to study the interaction of compounds on kinase targets in intact living cells.

Bioassays & Screening

Aurelia Bioscience Ltd is a pre-clinical contract research company focusing on supplying biochemical and cell-based compound screening expertise to small to medium enterprise (SME) companies, universities, research institutes, charities and large pharmaceuticals companies.

Our vision is to be recognised by our clients, partners and peers as a centre of excellence for these activities. Underlying this is a desire to continue to contribute to the discovery of new therapeutic compounds for unmet medical need.

CHI Discovery on Target Conference

Aurelia Bioscience exhibited at the CHI Discovery on Target 2019 conference in Boston from 16th-19th September.

Video on Protein-protein interactions

Watch this exciting video to learn more about our poster on 'Screening for inhibitors of protein: protein interactions in living cells: Development of assays to detect modulation of proteins using NanoBRET  technology': http://bit.ly/2KervD2.  Follow the link to...

Vacancy: Graduate Biologist

Aurelia Bioscience is offering a role for either a new graduate in biology or a graduate with some work experience who is looking for a new opportunity…

Validating innovative solutions in cell biology: A case study

New, innovative solutions in cell biology are constantly being developed to support biological research, and can be applied to the drug discovery process. However, in order to convince the scientific community of the promises these applications offer, they need to be validated…

CHI World Pre-clinical Congress

Aurelia Bioscience exhibited and presented a poster on 'Magnetic Electrospun Micro-fibre Scaffold Assemblies: Examples of their use for 3-Dimensional Cell-Based Screening Applications' at CHI World Pre-clinical Congress in Boston. Follow the link to download the poster.

2nd RSC Anglo-Nordic Medicinal Chemistry Symposium

Aurelia Bioscience exhibited and presented a poster on 'Prosecution of CDK family using NanoBRET Intracellular Engagement' at the 2nd RSC Anglo-Nordic Medicinal Chemistry Symposium in Snekkersten, Denmark. Contact the team for a copy of the poster.

Capabilities

High Throughput Screening

High Throughput Screening

With over 20 years of screening experience we are adept at designing and screening over 100,000 to 1 million compounds in 384 and 1536 well plates.

Cell Culture Services

Cell Culture Services

With over 30 years of experience we are adept at all aspects of cell culture.

Phenotypic Screening

Phenotypic Screening

We specialise in physiologically relevant assays using predominantly cell-based formats in state of the art technologies.

Bio Chemical Screening

Bio Chemical Screening

Our team has extensive experience of developing and screening compounds in biochemical assays for a range of targets including but not limited to proteases, kinases, and phosphodiesterase enzymes and protein:protein interaction.

Cell-Based Screening

Cell-Based Screening

Cell based assays are of key importance at a number of stages in the drug discovery process. Being able to examine the interaction between your target and compounds in a cellular context is of great advantage.

Label-Free Screening

Label-Free Screening

Our scientists have in-depth experience of label-free technology applied to cell-based assays gained over the past 6 years using Coring EPIC, Perkin Elmer EnSpire and SRU Bioscience Bind instruments.

FLIPR Screening

FLIPR Screening

We have used FLIPR in a range of assay formats, readouts and target types.

FMAT Screening

FMAT Screening

The 8200 Cellular Detection System (Fluorescent Microvolume Assay Technology – FMAT) from Applied Biosystems is a laser scanning macro-confocal fluorescent plate reader.

High Content Screening

High Content Screening

We have used the Ultra and Micro HCS imaging devices in a range of assay formats involving different target types.

Our People

Scientists at Aurelia have decades of experience between them working in real-world drug discovery projects utilising FLIPR, FMAT, EPIC label free and Envision-based assays in both biochemical and cell-based formats

Services

Fee for Service

Fee for Service

A comprehensive service to drug discovery clients including assay development, reagent testing and scale-up, proof of technology concept and validation, phenotypic screening and consultancy.

Drug Discovery Project

Drug Discovery Project

The members of Aurelia Bioscience have been involved in the design and development of many drug discovery projects incorporating complex biology and implementing a suite of assays designed to identify “active” compounds and improve their biological properties.

Instrument & Reagent Development

Instrument & Reagent Development

Acting as an intermediary between instrument and reagent manufacturers and prospective clients we can provide an expert lab-based environment for the validation of new technologies.